6/19/2023 0 Comments Labeling loops in stella architectOur findings demonstrate for the first time two different structural orientations of CLIC1 within phospholipid monolayers, depend. In this study, X-ray and neutron reflectivity experiments were performed to study the interaction of CLIC1 with different phospholipid monolayers prepared using POPC, POPE or POPS with and without cholesterol in order to better understand the regulatory role of cholesterol on CLIC1 membrane insertion. However, the precise physiological mechanism regulating CLIC1 membrane insertion is currently unknown. This conversion is regulated by the membrane lipid composition especially cholesterol together with external factors such as oxidation and pH. The CLICs are unusual in that they exist mainly as soluble proteins but possess the intriguing property of spontaneous conversion from the soluble to an integral membrane-bound form. ![]() more CLIC1 belongs to the ubiquitous family of Chloride Intracellular Ion Channel proteins that are evolutionarily conserved across species. ![]() CLIC1 belongs to the ubiquitous family of Chloride Intracellular Ion Channel proteins that are ev.
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